Repository Public
1{2 "page_meta": {3 "limit": 20,4 "next": null,5 "offset": 0,6 "previous": null,7 "total_count": 18 },9 "mechanisms": [10 {11 "action_type": "INHIBITOR",12 "binding_site_comment": null,13 "direct_interaction": 1,14 "disease_efficacy": 1,15 "max_phase": 4,16 "mec_id": 5260,17 "mechanism_comment": "Binds irreversibly to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion)",18 "mechanism_of_action": "Epidermal growth factor receptor erbB1 inhibitor",19 "mechanism_refs": [20 {21 "ref_id": "setid=5e81b4a7-b971-45e1-9c31-29cea8c87ce7",22 "ref_type": "DailyMed",23 "ref_url": "http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e81b4a7-b971-45e1-9c31-29cea8c87ce7"24 },25 {26 "ref_id": "24893891",27 "ref_type": "PubMed",28 "ref_url": "http://europepmc.org/abstract/MED/24893891"29 },30 {31 "ref_id": "25271963",32 "ref_type": "PubMed",33 "ref_url": "http://europepmc.org/abstract/MED/25271963"34 }35 ],36 "molecular_mechanism": 1,37 "molecule_chembl_id": "CHEMBL3353410",38 "parent_molecule_chembl_id": "CHEMBL3353410",39 "record_id": 2473534,40 "selectivity_comment": null,41 "site_id": null,42 "target_chembl_id": "CHEMBL203",43 "variant_sequence": null44 }45 ]46}