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mechanism-osimertinib.json 1.2 KB 46 lines json

1{2 "page_meta": {3  "limit": 20,4  "next": null,5  "offset": 0,6  "previous": null,7  "total_count": 18 },9 "mechanisms": [10  {11   "action_type": "INHIBITOR",12   "binding_site_comment": null,13   "direct_interaction": 1,14   "disease_efficacy": 1,15   "max_phase": 4,16   "mec_id": 5260,17   "mechanism_comment": "Binds irreversibly to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion)",18   "mechanism_of_action": "Epidermal growth factor receptor erbB1 inhibitor",19   "mechanism_refs": [20    {21     "ref_id": "setid=5e81b4a7-b971-45e1-9c31-29cea8c87ce7",22     "ref_type": "DailyMed",23     "ref_url": "http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e81b4a7-b971-45e1-9c31-29cea8c87ce7"24    },25    {26     "ref_id": "24893891",27     "ref_type": "PubMed",28     "ref_url": "http://europepmc.org/abstract/MED/24893891"29    },30    {31     "ref_id": "25271963",32     "ref_type": "PubMed",33     "ref_url": "http://europepmc.org/abstract/MED/25271963"34    }35   ],36   "molecular_mechanism": 1,37   "molecule_chembl_id": "CHEMBL3353410",38   "parent_molecule_chembl_id": "CHEMBL3353410",39   "record_id": 2473534,40   "selectivity_comment": null,41   "site_id": null,42   "target_chembl_id": "CHEMBL203",43   "variant_sequence": null44  }45 ]46}
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